Arakawa H, Mutoh S, Hirosumi J, Yamaguchi I
Tsukuba Research Laboratories, Fujisawa Pharmaceutical Company, Ibaraki, Japan.
J Cardiovasc Pharmacol. 1992;20(5):731-4.
The effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery was examined in miniature pigs. A diffuse intimal thickening was observed in vehicle-treated controls 6 weeks after balloon catheterization. The histologic features of the intimal thickening resembled those of early atherosclerotic lesions and restenosis after percutaneous transluminal coronary angioplasty (PTCA). Nilvadipine given in a daily dose of 10 mg/kg (subcutaneously, s.c.) for 6 weeks significantly inhibited intimal thickening. The ratio of the cross-sectional area of the intima to the cross-sectional area of the media was significantly reduced by 62% in nilvadipine-treated animals. These results suggest that nilvadipine may prevent or exert beneficial effects on coronary arterial injuries such as atherosclerosis and restenosis after PTCA.
在小型猪中研究了尼伐地平对球囊导管插入术诱导的冠状动脉内膜增厚的影响。在球囊导管插入术后6周，在给予赋形剂的对照组中观察到弥漫性内膜增厚。内膜增厚的组织学特征类似于早期动脉粥样硬化病变和经皮腔内冠状动脉成形术（PTCA）后的再狭窄。以10mg/kg的日剂量（皮下注射，s.c.）给予尼伐地平6周可显著抑制内膜增厚。在接受尼伐地平治疗的动物中，内膜横截面积与中膜横截面积之比显著降低了62%。这些结果表明，尼伐地平可能预防PTCA后的动脉粥样硬化和再狭窄等冠状动脉损伤或对其发挥有益作用。
