Mendhekar D N, Gupta D, Girotra V
Department of Psychiatry, GB Pant Hospital, New Delhi,
Acta Psychiatr Scand. 2003 Jul;108(1):70-4. doi: 10.1034/j.1600-0447.2003.00080.x.
Antidepressants including selective serotonin reuptake inhibitor (SSRI)-associated mania or hypomania has been well documented in the literature but these patients with switch have either mood disorders or various risk factors for bipolar disorder. This case report examines SSRI-induced hypomania in a patient with dissociative disorder and highlights hypomania as a genuine side-effect of sertraline rather than a switch.
A 23-year-old female patient with dissociative disorder has been described.
Hypomanic symptoms emerged during treatment with sertraline at the dose of 50 mg/day after 3-4 days of initiation of therapy and had complete recovery within 7 days after stopping sertraline.
In the absence of risk factors for manic switch, sertraline-induced hypomania may be a true side-effect of drug.
包括选择性5-羟色胺再摄取抑制剂(SSRI)相关的躁狂或轻躁狂在内的抗抑郁药已在文献中有充分记载,但这些出现转换的患者要么患有情绪障碍,要么有双相情感障碍的各种风险因素。本病例报告研究了一名患有分离性障碍的患者中SSRI诱发的轻躁狂,并强调轻躁狂是舍曲林的一种真正副作用而非转换。
描述了一名23岁患有分离性障碍的女性患者。
在开始使用舍曲林治疗3 - 4天后,以50毫克/天的剂量出现轻躁狂症状,在停用舍曲林后7天内完全恢复。
在没有躁狂转换风险因素的情况下,舍曲林诱发的轻躁狂可能是药物的一种真正副作用。