未成熟的树突状细胞拥有一种对人甘露聚糖结合凝集素敏感的糖受体。
Immature dendritic cells possess a sugar-sensitive receptor for human mannan-binding lectin.
作者信息
Downing Ian, Koch Claus, Kilpatrick David C
机构信息
Cell Therapy Group, S.N.B.T.S. National Science Laboratory, Edinburgh, UK.
出版信息
Immunology. 2003 Jul;109(3):360-4. doi: 10.1046/j.1365-2567.2003.01675.x.
Abstract
Mannan-binding lectin (MBL) is a collectin synthesized by the liver and secreted into the bloodstream. It has a receptor for microbial structures in its C-type lectin domain and a separate receptor(s) located within its collagen-like region for autologous phagocytic cells. Here we demonstrate that human peripheral blood adherent cells (monocytes) and monocyte-derived dendritic cells are a source of MBL, and that a novel calcium-dependent and sugar-specific MBL receptor is up-regulated in immature (CD1a-positive) dendritic cells. These findings suggest a previously unsuspected autologous function for MBL, perhaps a regulatory role within the immune system.
摘要
甘露聚糖结合凝集素（MBL）是一种由肝脏合成并分泌到血液中的凝集素。它在其C型凝集素结构域中有一个针对微生物结构的受体，在其胶原样区域内有一个针对自体吞噬细胞的单独受体。在此我们证明，人外周血贴壁细胞（单核细胞）和单核细胞衍生的树突状细胞是MBL的来源，并且一种新型的钙依赖性和糖特异性MBL受体在未成熟（CD1a阳性）树突状细胞中上调。这些发现提示了MBL一种以前未被怀疑的自体功能，可能在免疫系统中起调节作用。
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