Downing Ian, Koch Claus, Kilpatrick David C
Cell Therapy Group, S.N.B.T.S. National Science Laboratory, Edinburgh, UK.
Immunology. 2003 Jul;109(3):360-4. doi: 10.1046/j.1365-2567.2003.01675.x.
Mannan-binding lectin (MBL) is a collectin synthesized by the liver and secreted into the bloodstream. It has a receptor for microbial structures in its C-type lectin domain and a separate receptor(s) located within its collagen-like region for autologous phagocytic cells. Here we demonstrate that human peripheral blood adherent cells (monocytes) and monocyte-derived dendritic cells are a source of MBL, and that a novel calcium-dependent and sugar-specific MBL receptor is up-regulated in immature (CD1a-positive) dendritic cells. These findings suggest a previously unsuspected autologous function for MBL, perhaps a regulatory role within the immune system.
甘露聚糖结合凝集素（MBL）是一种由肝脏合成并分泌到血液中的凝集素。它在其C型凝集素结构域中有一个针对微生物结构的受体，在其胶原样区域内有一个针对自体吞噬细胞的单独受体。在此我们证明，人外周血贴壁细胞（单核细胞）和单核细胞衍生的树突状细胞是MBL的来源，并且一种新型的钙依赖性和糖特异性MBL受体在未成熟（CD1a阳性）树突状细胞中上调。这些发现提示了MBL一种以前未被怀疑的自体功能，可能在免疫系统中起调节作用。
