Zaretsky Malcolm D
Department of Molecular and Cell Biology, University of California at Berkeley, 94720-3206, USA.
J Gerontol A Biol Sci Med Sci. 2003 Jun;58(6):566-72. doi: 10.1093/gerona/58.6.m566.
Longevity is greater for identical twins than for fraternal twins from the same population. Factors that are explanatory for this difference are not known.
Multivariate survival analysis is applied to current mortality data for 26,974 male twins with known zygosities of the National Academy of Science-National Research Council World War II Veteran Twins Registry, and this analysis is applied to their health and social behavior and personal histories, as collected from two survey questionnaires distributed in 1967 and 1983 (with 14,300 and 9475 responses received, respectively). To explain this difference in longevity, social, health, and personal history factors are evaluated for associations with longevity.
Survival functions of identical and fraternal twins differed significantly (p<.0001). Median lifetimes were 82 years for identical and 80.5 years for fraternal twins. The correlation between lifetimes of identical twin partners was greater than that of fraternal twins. For identical but not for fraternal twins, the risk of mortality was significantly lower for twin partners who communicated 1 or more times per month, compared with those who communicated less frequently (relative risk.80, 95% confidence interval 0.68-0.94, p=.008, with control for other factors associated with longevity: smoking, exercise, a current marriage, living with both parents until age 15 or older, and having a live co-twin). Distributions of communication, exercise level, and smoking prevalence were more beneficial with regard to longevity for identical than for fraternal twins as a group.
Frequent communication between identical but not fraternal twin partners, and both level of exercise and prevalence of smoking, distributed more beneficially in terms of longevity for identical compared with fraternal twins, are explanatory for the greater longevity of identical than fraternal twins.
同卵双胞胎的寿命比来自同一人群的异卵双胞胎更长。导致这种差异的因素尚不清楚。
对美国国家科学院 - 国家研究委员会二战退伍军人双胞胎登记处的26974名已知合子性的男性双胞胎的当前死亡率数据进行多变量生存分析，并将该分析应用于他们的健康、社会行为和个人病史，这些信息来自于1967年和1983年分发的两份调查问卷（分别收到14300份和9475份回复）。为了解释这种寿命差异，对社会、健康和个人病史因素与寿命的关联进行评估。
同卵双胞胎和异卵双胞胎的生存函数存在显著差异（p <.0001）。同卵双胞胎的中位寿命为82岁，异卵双胞胎为80.5岁。同卵双胞胎伴侣寿命之间的相关性大于异卵双胞胎。对于同卵双胞胎而非异卵双胞胎，每月交流1次或更多次的双胞胎伴侣与交流较少的伴侣相比，死亡风险显著更低（相对风险0.80，95%置信区间0.68 - 0.94，p =.008，同时控制了与寿命相关的其他因素：吸烟、运动、当前婚姻状况、15岁及以上与双亲同住以及有存活的双胞胎同胞）。作为一个群体，同卵双胞胎在交流、运动水平和吸烟流行率的分布方面，就寿命而言比异卵双胞胎更有益。
同卵双胞胎伴侣之间的频繁交流，以及运动水平和吸烟流行率在同卵双胞胎中比异卵双胞胎在寿命方面分布更有益，这解释了同卵双胞胎比异卵双胞胎寿命更长的原因。
