Gregersen P K
Cornell University Medical College, New York.
Rheum Dis Clin North Am. 1992 Nov;18(4):793-807.
Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.
类风湿性关节炎（RA）是一种复杂的多因素疾病。有人提出，参与免疫识别的多个基因相互作用，产生类风湿性关节炎的遗传易感性状态。本文讨论了HLA、T细胞受体和其他背景基因的作用，重点是它们在塑造T细胞库中的作用。
