类风湿关节炎中T细胞受体与主要组织相容性复合体的基因相互作用
T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis.
作者信息
Gregersen P K
机构信息
Cornell University Medical College, New York.
出版信息
Rheum Dis Clin North Am. 1992 Nov;18(4):793-807.
PMID:1280847
Abstract
Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.
摘要
类风湿性关节炎（RA）是一种复杂的多因素疾病。有人提出，参与免疫识别的多个基因相互作用，产生类风湿性关节炎的遗传易感性状态。本文讨论了HLA、T细胞受体和其他背景基因的作用，重点是它们在塑造T细胞库中的作用。
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