Vinci Paolo, Esposito Carolina, Perelli Sandra L, Antenor Jo Ann V, Thomas Florian P
Department of Rehabilitation of Charcot-Marie-Tooth Disease and Other Neuromuscular Disorders, Specialized Rehabilitation Hospital L. Spolverini, Ariccia, Rome, Italy.
Arch Phys Med Rehabil. 2003 Jun;84(6):825-7. doi: 10.1016/s0003-9993(02)04949-3.
To determine the incidence of overwork weakness in Charcot-Marie-Tooth disease (CMT).
Prospective survey.
Rehabilitation department for CMT in an Italian tertiary care hospital.
A total of 106 outpatients with CMT, selected for absence of other causes of weakness (age range, 11-69y), and 48 healthy volunteers (controls).
The strength of 2 intrinsic hand muscles (abductor pollicis brevis [APB], first dorsal interosseous) in the dominant and nondominant hands was graded by using manual muscle testing and a modified Medical Research Council (MRC) Scale.
The side of the stronger muscle and the difference in strength between the nondominant and dominant muscles.
Muscles were stronger on the nondominant side in 65.57% of patients versus 1.04% of controls, and on the dominant side in .94% of patients versus 84.38% controls. The difference in strength for first dorsal interosseous was .51 in patients and -.32 in controls (P>.01). The difference in strength for APB was .65 in patients and -.35 in controls (P>.01).
CMT muscles in the dominant hand are weaker than in the nondominant hand. This may be the result of overwork weakness.
确定夏科-马里-图斯病（CMT）中过劳性肌无力的发生率。
前瞻性调查。
意大利一家三级护理医院的CMT康复科。
共106例CMT门诊患者，入选标准为无其他导致肌无力的原因（年龄范围11 - 69岁），以及48名健康志愿者（对照组）。
使用徒手肌力测试和改良的医学研究委员会（MRC）量表对优势手和非优势手的2块手部固有肌（拇短展肌[APB]、第一背侧骨间肌）的肌力进行分级。
肌力较强的一侧以及非优势肌与优势肌之间的肌力差异。
65.57%的患者非优势侧肌肉更强，而对照组为1.04%；0.94%的患者优势侧肌肉更强，而对照组为84.38%。第一背侧骨间肌患者的肌力差异为0.51，对照组为 - 0.32（P>0.01）。APB患者的肌力差异为0.65，对照组为 - 0.35（P>0.01）。
CMT患者优势手的肌肉比非优势手弱。这可能是过劳性肌无力的结果。
