Gorgan V, Gidaly M, Serban I, Belu M, Onesciuc I
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1975 Jan-Mar;20(1):41-5.
The present paper reports on 34 cases of meningococcal meningitis admitted during the last three years to the Clinic of Communicable Diseases of Cluj. The incidence was higher in adolescents and young adults (76%). The clinical form was severe in 10 cases, medium in 19 cases and mild in 5 cases. All the patients recovered, with a mean duration of the disease of 9-12 days. No sequelae or relapses were recorded. The treatment was based upon penicillin G, 15 million U/day. In 17 cases sulfonamides were associated and in 5 cases chloramphenicol and ampicillin. In 29 cases intravenous, intramuscular or oral cortisone was administered and in 5 cases intrathecally. The results obtained in the cases treated only with penicillin were identical to those obtained by an associated therapy. Worthy of note was the decrease of the sensitivity of meningococci to sulfonamides and chloramphenicol and their increased resistance to tetracyclin and erythromycin.
本文报道了过去三年中克卢日传染病诊所收治的34例脑膜炎球菌性脑膜炎病例。青少年和年轻人的发病率较高（76%）。临床症状严重的有10例，中等的有19例，轻微的有5例。所有患者均康复，疾病平均持续时间为9至12天。未记录到后遗症或复发情况。治疗以青霉素G为基础，每日1500万单位。17例联合使用了磺胺类药物，5例联合使用了氯霉素和氨苄青霉素。29例给予了静脉、肌肉或口服皮质激素，5例给予了鞘内注射。仅用青霉素治疗的病例所获得的结果与联合治疗所获得的结果相同。值得注意的是，脑膜炎球菌对磺胺类药物和氯霉素的敏感性降低，对四环素和红霉素的耐药性增加。
