作为介质释放模型的寒冷性荨麻疹：血小板因子4、嗜酸性粒细胞阳离子蛋白和组胺。

Cold urticaria as a model of mediator release: platelet factor 4, eosinophil cationic protein and histamine.

作者信息

Rosenkranz A R, Wekkeli M, Hippmann G, Benda H, Jarisch R, Götz M

机构信息

Dermatologic and Pediatric Allergy Clinic, Vienna, Austria.

出版信息

Allergy. 1992 Aug;47(4 Pt 2):366-70. doi: 10.1111/j.1398-9995.1992.tb02073.x.

DOI:10.1111/j.1398-9995.1992.tb02073.x

PMID:1280916

Abstract

Platelet factor 4 (PF4) has previously been linked to precipitation of cold urticaria (CU). The aim of the study was to assess the liberation of PF4, eosinophil cationic protein (ECP) and histamine after cold challenge in patients with CU. Ten controls and 8 patients with CU verified by clinical data and cold challenge test were investigated. Assessment of histamine, ECP and PF4 were done using radioimmunoassays. In patients histamine increased after 10 min on the challenged arm (NS), PF4 increase was statistically significant (p less than 0.05) both in patients and controls. ECP release showed no significant changes. Treatment with doxepin results in clinical improvement, but no changes in mediator release were seen. Thus, in contrast to previous reports an increase of PF4 was seen both in controls as well as in patients. An involvement of ECP was not ascertained. Our data suggest that neither basophils, nor eosinophils or platelets are directly involved in cold urticaria and that mast cell-dependent mediators may be of greater relevance.

摘要

血小板因子4（PF4）此前已被认为与寒冷性荨麻疹（CU）的发作有关。本研究的目的是评估CU患者在冷刺激后PF4、嗜酸性粒细胞阳离子蛋白（ECP）和组胺的释放情况。对10名对照者和8名经临床数据及冷刺激试验证实的CU患者进行了研究。使用放射免疫分析法对组胺、ECP和PF4进行评估。在患者中，受刺激手臂在10分钟后组胺增加（无统计学意义），PF4的增加在患者和对照者中均具有统计学意义（p<0.05）。ECP释放无显著变化。多塞平治疗可使临床症状改善，但未观察到介质释放的变化。因此，与先前的报道相反，在对照者和患者中均观察到PF4增加。未确定ECP的参与情况。我们的数据表明，嗜碱性粒细胞、嗜酸性粒细胞或血小板均未直接参与寒冷性荨麻疹，肥大细胞依赖性介质可能更具相关性。