Graham S, Follett E A, Wallace L, Desselberger U, Marsden H S
MRC Virology Unit, Institute of Virology, Glasgow, Scotland.
AIDS Res Hum Retroviruses. 1992 Oct;8(10):1781-8. doi: 10.1089/aid.1992.8.1781.
Immunodominant antibody-binding sites were mapped using overlapping synthetic peptides of the structural proteins p17 and p24 of human immunodeficiency virus type 1 (HIV-1). Using sera from HIV-1-infected individuals at a variety of disease states, three major epitopes were identified within p17 and one within p24. Antibodies which recognized these epitopes were present in all risk groups throughout all stages of HIV infection, regardless of the presence of high levels of serum p24 antigen.
利用人类免疫缺陷病毒1型（HIV-1）结构蛋白p17和p24的重叠合成肽对免疫显性抗体结合位点进行了定位。使用处于各种疾病状态的HIV-1感染个体的血清，在p17内鉴定出三个主要表位，在p24内鉴定出一个主要表位。识别这些表位的抗体在HIV感染的所有阶段存在于所有风险组中，而与血清p24抗原水平高无关。
