Kraus W Lee, Lis John T
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Cell. 2003 Jun 13;113(6):677-83. doi: 10.1016/s0092-8674(03)00433-1.
PARP-1, an enzyme that catalyzes the attachment of ADP ribose units to target proteins, plays at least two important roles in transcription regulation. First, PARP-1 modifies histones and creates an anionic poly(ADPribose) matrix that binds histones, thereby promoting the decondensation of higher-order chromatin structures. Second, PARP-1 acts as a component of enhancer/promoter regulatory complexes. Recent studies have shown that both of these activities are critical for gene regulation in vivo.
聚（ADP-核糖）聚合酶-1（PARP-1）是一种催化将ADP核糖单元连接到靶蛋白上的酶，在转录调控中至少发挥两个重要作用。首先，PARP-1修饰组蛋白并形成结合组蛋白的阴离子聚（ADP核糖）基质，从而促进高阶染色质结构的解聚。其次，PARP-1作为增强子/启动子调节复合物的一个组成部分发挥作用。最近的研究表明，这两种活性对于体内基因调控都至关重要。
