Imperiale Daniele, Pignatta Piero, Cerrato Paolo, Montalenti Elisa, Ravetti Carlo, Benna Paolo
Neurologic Unit-Maria Vittoria Hospital, Torino, Italy.
Seizure. 2003 Jul;12(5):319-22. doi: 10.1016/s1059-1311(02)00293-5.
We describe a 30-year-old woman with an infantile-onset epilepsy due to a left temporal gliotic area who developed a nonconvulsive status epilepticus (NCSE) during tiagabine (TGB) adjunctive therapy. The ictal EEG recording showed a de novo right temporal focus not previously evident. After the i.v. administration of 4 mg lorazepam, the NCSE episode rapidly resolved and her usual left temporal EEG abnormalities reappeared. To our knowledge this is the first case of paradoxical seizure exacerbation associated with TGB therapy in which the clinical and EEG features are congruous with a new contralateral focus.
