Winiarski Marek, Bielanski Wladyslaw, Plonka Małgorzata, Dobrzanska Maria, Kaminska Anna, Bobrzynski Andrzej, Ronturek Peter C, Konturek Stanislaur J
Department of General Surgery, Jagiellonian University College of Medicine, Krakow, Poland.
J Clin Gastroenterol. 2003 Jul;37(1):34-8. doi: 10.1097/00004836-200307000-00010.
H. pylori infection and peptic ulcerations and their complications such as bleeding are causally related, but the available methods used in bleeding to confirm active H. pylori lack accuracy. AIM To evaluate the usefulness of 13C-urea breath test (UBT) in diagnosing of H. pylori infection in bleeding patients.
Eighty-one patients with upper gastrointestinal bleeding and 258 matched controls without bleeding were enrolled to the study. UBT was performed using low-dose capsulated 13C-urea and IgG antibodies to H. pylori were determined by ELISA.
UBT performed in bleeding patients was positive in 77.7%. In this group anti Hp IgG was positive in 79% of cases and among them gastroscopy showed 40.7% of bleeding duodenal ulcer, 38% bleeding gastric ulcer, and 86% hemorrhagic gastritis. UBT was positive in 90.9%, 77.4%, and in 52.97% cases, respectively, and it was not statistically different from that in non-bleeding controls, duodenal and gastric ulcers and gastritis. All patients with blood or "coffee grounds" in the stomach had both UBT and serology positive.
The UBT is simple and non-invasive method, which can be successively applied also in patients with upper gastrointestinal bleeding to detect active H. pylori infection prior to emergency endoscopy.
幽门螺杆菌感染与消化性溃疡及其并发症（如出血）存在因果关系，但目前用于出血时确认幽门螺杆菌活跃感染的方法缺乏准确性。目的：评估¹³C尿素呼气试验（UBT）在诊断出血患者幽门螺杆菌感染中的实用性。
81例上消化道出血患者和258例匹配的无出血对照者纳入本研究。使用低剂量胶囊装¹³C尿素进行UBT，并通过酶联免疫吸附测定法测定抗幽门螺杆菌IgG抗体。
出血患者中UBT阳性率为77.7%。该组中抗幽门螺杆菌IgG阳性率为79%，其中胃镜检查显示40.7%为出血性十二指肠溃疡，38%为出血性胃溃疡，86%为出血性胃炎。在十二指肠溃疡、胃溃疡和胃炎患者中，UBT阳性率分别为90.9%、77.4%和52.97%，与无出血对照者相比无统计学差异。所有胃内有血液或“咖啡渣样物”的患者UBT和血清学均为阳性。
UBT是一种简单且无创的方法，也可成功应用于上消化道出血患者，在急诊内镜检查前检测幽门螺杆菌活跃感染。
Zotero 插件