Docampo Roberto, Moreno Silvia N J
Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.
Parasitol Res. 2003 Jun;90 Supp 1:S10-3. doi: 10.1007/s00436-002-0752-y. Epub 2002 Nov 23.
Human African trypanosomiasis is a fatal disease caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense that has re-emerged in recent years. However, very little progress has been made in the development of new drugs against this disease. Most drugs still in use were developed one or more decades ago, and are generally toxic and of limited effectiveness. The most recently introduced compound, eflornithine, is only useful against sleeping sickness caused by T. b. gambiense, and is prohibitively expensive for the African developing countries. We present here an overview of today's approved and clinically used drugs against this disease.
人类非洲锥虫病是一种由布氏冈比亚锥虫和布氏罗得西亚锥虫引起的致命疾病，近年来再度出现。然而，在开发针对这种疾病的新药方面进展甚微。目前仍在使用的大多数药物是在几十年前开发的，通常具有毒性且疗效有限。最近引入的化合物依氟鸟氨酸仅对布氏冈比亚锥虫引起的昏睡病有效，对非洲发展中国家来说价格高得令人望而却步。我们在此概述当今已获批准并临床使用的针对这种疾病的药物。
