Jørgensen P E, Nexø E, Poulsen S S, Raaberg L
Department B, University of Copenhagen, Denmark.
Agents Actions Suppl. 1992;38 ( Pt 2):183-90.
Epidermal growth factor (EGF) is synthesized as a membrane bound precursor in the rat kidney. The precursor seems to be processed by an aprotinin sensitive proteinase. Intravenous infusion of aprotinin reduces the urinary excretion of EGF by 85% and increases the amount of renal EGF. Kidney membranes incubated at 37 degrees C release EGF and this release is inhibited by aprotinin.
