Lembeck F, Griesbacher T, Legat F J
Department of Experimental and Clinical Pharmacology, University of Graz, Austria.
Agents Actions Suppl. 1992;38 ( Pt 2):414-22.
The novel, potent and long-acting bradykinin (BK) antagonists, HOE 140, compound II and compound III, slightly decreased blood pressure, but did not affect heart rate and respiration of rats. The antagonists did not cause bronchoconstriction in guinea-pigs. Neither HOE 140 nor BK released histamine from isolated perfused hindlegs of rats. The lack of significant unspecific side effects of the novel antagonists of effective doses will further increase the usefulness of these compounds for experimental and therapeutic purposes.
新型、强效且长效的缓激肽（BK）拮抗剂HOE 140、化合物II和化合物III可使大鼠血压略有下降，但不影响其心率和呼吸。这些拮抗剂不会引起豚鼠支气管收缩。HOE 140和BK均不会使大鼠离体灌注后肢释放组胺。有效剂量的新型拮抗剂缺乏明显的非特异性副作用，这将进一步提高这些化合物在实验和治疗方面的实用性。
