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儿童脑膜炎球菌病的临床表现——来自一家儿科急诊科的五年经验

Presenting features of paediatric meningococcal disease--a five year experience from a paediatric accident and emergency department.

作者信息

Leonard P A, Beattie T F

机构信息

Accident and Emergency Department, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh.

出版信息

Health Bull (Edinb). 2000 Mar;58(2):148-51.

Abstract

OBJECTIVES

To determine the clinical features, initial management and outcome of meningococcal disease presenting to a paediatric accident and emergency (A&E) department.

DESIGN

A retrospective study of all cases of meningococcal disease seen in the department over a five year period.

SETTING

A paediatric A&E department which treats approximately 30,000 patients a year.

SUBJECTS

All children under the age of 13 years with a discharge diagnosis of meningococcal disease

RESULTS

Fifty patients, forty-six with microbiological confirmation of their diagnosis were identified. Sixty six percent of patients were seen first by their general practitioner. However only 28% had received prehospital parenteral antibiotics. Twenty six percent of children had neither meningism nor a classical purpuric rash, 60% showed signs of shock and 66% had an altered conscious level. The case fatality rate was 4%, with 78% making a full recovery.

CONCLUSION

Classical features of meningococcal disease are often absent. Assessing simple clinical parameters such as capillary refill, respiratory rate and conscious level adds to the detection of the disease. If meningococcal disease is suspected parental benzylpenicillin should be given and the child transferred to hospital.

摘要

目的

确定在儿科急诊部门就诊的脑膜炎球菌病的临床特征、初始治疗及预后。

设计

对该部门五年期间所有脑膜炎球菌病病例进行的回顾性研究。

地点

一家每年接诊约30000名患者的儿科急诊部门。

研究对象

所有出院诊断为脑膜炎球菌病的13岁以下儿童

结果

共确定50例患者,其中46例经微生物学确诊。66%的患者首先由其全科医生诊治。然而,只有28%的患者在院前接受了肠外抗生素治疗。26%的儿童既没有脑膜刺激征也没有典型的紫癜性皮疹,60%有休克体征,66%有意识水平改变。病死率为4%,78%的患者完全康复。

结论

脑膜炎球菌病的典型特征往往不存在。评估如毛细血管再充盈、呼吸频率和意识水平等简单临床参数有助于疾病的检测。如果怀疑是脑膜炎球菌病,应给予家长肌内注射苄青霉素,并将儿童转诊至医院。

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