Kozai Y, Ohyama T, Kodo H, Tomori G
Dept. of Transfusion Medicine, Tokyo Metropolitan Fuchu Hospital.
Gan To Kagaku Ryoho. 1992 Dec;19(14):2407-9.
Four patients with fresh Hodgkin's disease were treated with MOPP/ABV hybrid regimen using nitrogen mustard-N-oxide hydrochloride (NH2-O). All patients responded well to this therapy and achieved complete remission. Toxicity was minimum except for an older patient. He was 70 years old and developed arrhythmia after MOPP therapy but recovered without any treatment. The continuation of therapy was possible by dose reduction in this case. We conclude MOPP/ABV regimen using NH2-O is valuable for the treatment of Hodgkin's disease.
