纽约州多发性硬化症联盟中非洲裔美国患者的多发性硬化症特征
Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium.
作者信息
Weinstock-Guttman B, Jacobs L D, Brownscheidle C M, Baier M, Rea D F, Apatoff B R, Blitz K M, Coyle P K, Frontera A T, Goodman A D, Gottesman M H, Herbert J, Holub R, Lava N S, Lenihan M, Lusins J, Mihai C, Miller A E, Perel A B, Snyder D H, Bakshi R, Granger C V, Greenberg S J, Jubelt B, Krupp L, Munschauer F E, Rubin D, Schwid S, Smiroldo J
机构信息
William C. Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA.
出版信息
Mult Scler. 2003 Jun;9(3):293-8. doi: 10.1191/1352458503ms909oa.
The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in African American (AA) patients in the New York State Multiple Sclerosis Consortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AAs comprise 6% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in AA registrants versus nonAfrican Americans (NAA). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. AA patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.
本研究的目的是确定纽约州多发性硬化症联盟（NYSMSC）患者登记处中非裔美国人（AA）多发性硬化症（MS）患者的临床特征。NYSMSC是纽约州18个MS中心组成的团体，旨在前瞻性评估MS患者的临床特征。非裔美国人占NYSMSC总登记人数（5602人）的6%（329人）。对非裔美国人登记者与非非裔美国人（NAA）在人口统计学、病程、治疗和社会经济状况方面进行了比较。非裔美国人组女性占比更高，诊断时年龄显著更小。随着病程延长，非裔美国人患者更有可能出现更大程度的残疾。在MS类型和疾病修饰疗法的使用方面未发现差异。我们的研究结果表明种族对MS有影响。有必要进行进一步考虑种族差异的基因研究，以阐明疾病易感性机制。
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