Jusić A, Ries M, Sostarko M
Department of Neurology, Clinical Medical Center Rebro, Zagreb, Croatia.
Neurol Croat. 1992;41(4):213-26.
Amyotrophic lateral sclerosis (ALS) is a clinical entity differentiated during the last few years into definite, probable, possible and suspected ALS. There are many hypotheses trying to explain its genesis: slow virus hypothesis, trace elements, immunologic and trophic factors, excitotoxins, metabolic influences, DNA anomalies, and so on. It is necessary to differentiate ALS like syndromes and ALS variants. Some of the ALS like syndromes can be treated. Only the disease elaborated like that may be submitted to clinical therapeutical trials or molecular-genetic research. Palliative therapy is still necessary. It does not prolong life, it makes its quality better.
肌萎缩侧索硬化症（ALS）是近年来在临床上分为确诊、很可能、可能和疑似ALS的一种疾病实体。有许多假说试图解释其发病机制：慢病毒假说、微量元素、免疫和营养因子、兴奋性毒素、代谢影响、DNA异常等等。有必要区分ALS样综合征和ALS变异型。一些ALS样综合征是可以治疗的。只有如此详细阐述的疾病才可以进行临床治疗试验或分子遗传学研究。姑息治疗仍然是必要的。它不会延长生命，但会提高生活质量。
