认知储备与生活方式。
Cognitive reserve and lifestyle.
作者信息
Scarmeas Nikolaos, Stern Yaakov
机构信息
Cognitive Neuroscience Division, Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, and College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
出版信息
J Clin Exp Neuropsychol. 2003 Aug;25(5):625-33. doi: 10.1076/jcen.25.5.625.14576.
Abstract
The concept of cognitive reserve (CR) suggests that innate intelligence or aspects of life experience like educational or occupational attainments may supply reserve, in the form of a set of skills or repertoires that allows some people to cope with progressing Alzheimer's disease (AD) pathology better than others. There is epidemiological evidence that lifestyle characterized by engagement in leisure activities of intellectual and social nature is associated with slower cognitive decline in healthy elderly and may reduce the risk of incident dementia. There is also evidence from functional imaging studies that subjects engaging in such leisure activities can clinically tolerate more AD pathology. It is possible that aspects of life experience like engagement in leisure activities may result in functionally more efficient cognitive networks and therefore provide a CR that delays the onset of clinical manifestations of dementia.
摘要
认知储备（CR）的概念表明，先天智力或诸如教育程度或职业成就等生活经历方面可能以一组技能或能力的形式提供储备，使一些人比其他人更能应对阿尔茨海默病（AD）病情的进展。有流行病学证据表明，以参与智力和社交性质的休闲活动为特征的生活方式与健康老年人认知能力下降较慢有关，并且可能降低患痴呆症的风险。功能成像研究也有证据表明，参与此类休闲活动的受试者在临床上能够耐受更多的AD病理变化。像参与休闲活动这样的生活经历方面可能会导致认知网络在功能上更高效，从而提供一种认知储备，延缓痴呆症临床表现的出现，这是有可能的。
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