Susova O Iu, Gurtsevich V E
Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478.
Mol Biol (Mosk). 2003 May-Jun;37(3):392-403.
The review considers the molecular biological organization of genome region pX of the human T-cell leukemia virus type I (HTLV-I) along with the structure and functions of regulatory proteins Tax, Rex, and poorly studied Rof and Tof. Tax functions are described, including transcriptional trans-activation, trans-repression, and effects on apoptosis and the cell cycle. The roles of Tax and Rex in controlling gene expression and replication of HTLV-I are discussed.
这篇综述探讨了人类I型T细胞白血病病毒（HTLV-I）基因组pX区域的分子生物学组织，以及调节蛋白Tax、Rex，以及研究较少的Rof和Tof的结构与功能。文中描述了Tax的功能，包括转录反式激活、反式抑制，以及对细胞凋亡和细胞周期的影响。还讨论了Tax和Rex在控制HTLV-I基因表达和复制中的作用。
