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[重度急性哮喘]

[Severe acute asthma].

作者信息

Salmeron Sergio, Robin Marie-Luce, Kettaneh Laurence, Blanc François-Xavier

机构信息

Service de pneumologie Fondation Hôpital Saint-Joseph 75674 Paris.

出版信息

Rev Prat. 2003 May 1;53(9):945-9.

Abstract

A severe acute asthma attack is defined by the presence of clinical signs of severity and/or a value of peak expiratory flow (PEF) < 30% predicted. The treatment is based mainly on inhaled beta 2 agonists and systemic corticosteroids. Nebulization is the route of administration of choice, because of its simplicity, its efficacy and its tolerability. Anticholinergics are indicated in association with nebulised beta 2 agonists. Response to treatment must be evaluated within an hour, permitting the early detection of "responders" or "non-responders" to the initial treatment. The great majority of deaths from acute asthma are avoidable, underlining the importance of preventive measures. Prevention is based on the control of the asthma by personalized ongoing treatment based on long-term inhaled corticosteroids and the use of oral corticosteroids in the treatment of exacerbations. However, a severe acute asthma attack can appear at any stage of severity of asthma, including controlled asthma, justifying the utilisation of action plans to treat exacerbations.

摘要

严重急性哮喘发作的定义为存在严重程度的临床体征和/或呼气峰值流速(PEF)<预测值的30%。治疗主要基于吸入β2激动剂和全身性皮质类固醇。雾化是首选给药途径,因其操作简便、疗效好且耐受性佳。抗胆碱能药物与雾化β2激动剂联合使用。必须在一小时内评估治疗反应,以便早期发现对初始治疗的“反应者”或“无反应者”。急性哮喘导致的绝大多数死亡是可以避免的,这凸显了预防措施的重要性。预防基于通过长期吸入皮质类固醇进行个性化持续治疗来控制哮喘,并在加重期使用口服皮质类固醇。然而,严重急性哮喘发作可出现在哮喘严重程度的任何阶段,包括控制良好的哮喘,这证明了使用行动计划来治疗加重期的合理性。

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