系统性红斑狼疮发病机制中的遗传和免疫机制。
Genetic and immunological mechanisms in the pathogenesis of systemic lupus erythematosus.
作者信息
Drake C G, Kotzin B L
机构信息
Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
出版信息
Curr Opin Immunol. 1992 Dec;4(6):733-40. doi: 10.1016/0952-7915(92)90054-i.
PMID:1281640
Abstract
Recent research in systemic lupus erythematosus and animal models of lupus has provided new insight into the pathogenesis of this complex autoimmune disease. Progress has been made towards understanding the genetic contributions to disease susceptibility and induction, as well as towards elucidation of the lymphocyte abnormalities involved in pathogenic autoantibody production.
摘要
近期关于系统性红斑狼疮及狼疮动物模型的研究，为这种复杂自身免疫性疾病的发病机制提供了新的见解。在理解疾病易感性和诱发的遗传因素方面，以及在阐明致病性自身抗体产生过程中涉及的淋巴细胞异常方面，均取得了进展。
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