非节段性白癜风与自身免疫机制。
Nonsegmental vitiligo and autoimmune mechanism.
作者信息
Oiso Naoki, Suzuki Tamio, Fukai Kazuyoshi, Katayama Ichiro, Kawada Akira
机构信息
Department of Dermatology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
出版信息
Dermatol Res Pract. 2011;2011:518090. doi: 10.1155/2011/518090. Epub 2011 Jul 26.
Abstract
Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo.
摘要
非节段性白癜风是一种皮肤色素脱失性疾病，表现为皮肤、黏膜和毛发出现后天性、进行性色素脱失性损害。据信其主要由受累部位黑素细胞的自身免疫性丧失所致。它常与其他自身免疫性疾病相关，尤其是自身免疫性甲状腺疾病，包括桥本甲状腺炎和格雷夫斯病、类风湿关节炎、1型糖尿病、银屑病、恶性贫血、系统性红斑狼疮、艾迪生病和斑秃。这表明不仅对白癫风，而且对其他自身免疫性疾病存在遗传决定的易感性。在此，我们总结了目前对非节段性白癜风自身免疫发病机制的认识。
相似文献
1
Nonsegmental vitiligo and autoimmune mechanism.非节段性白癜风与自身免疫机制。
Dermatol Res Pract. 2011;2011:518090. doi: 10.1155/2011/518090. Epub 2011 Jul 26.
2
Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families.日本患者及其家族中的泛发性白癜风及相关自身免疫性疾病。
Allergol Int. 2011 Dec;60(4):505-8. doi: 10.2332/allergolint.11-OA-0303. Epub 2011 Jul 25.
3
Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo.家族性泛发性白癜风的疾病早发及其他自身免疫性疾病风险增加。
Pigment Cell Res. 2005 Aug;18(4):300-5. doi: 10.1111/j.1600-0749.2005.00242.x.
4
Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK.自身免疫性疾病随时间推移以及按年龄、性别和社会经济状况的发生率、患病率和共病情况：英国 2200 万人的基于人群队列研究。
Lancet. 2023 Jun 3;401(10391):1878-1890. doi: 10.1016/S0140-6736(23)00457-9. Epub 2023 May 5.
5
Comorbidities in vitiligo: comprehensive review.白癜风的合并症：全面综述。
Int J Dermatol. 2018 Oct;57(10):1157-1164. doi: 10.1111/ijd.14055. Epub 2018 May 28.
6
Association of vitiligo with multiple cutaneous and extra-cutaneous autoimmune diseases: a nationwide cross-sectional study.白癜风与多种皮肤及皮肤外自身免疫性疾病的关联：一项全国性横断面研究。
Arch Dermatol Res. 2023 Nov;315(9):2597-2603. doi: 10.1007/s00403-023-02661-y. Epub 2023 Jul 5.
7
Behçet's syndrome is not associated with vitiligo.白塞病与白癜风无关。
Clin Exp Rheumatol. 2008 Jul-Aug;26(4 Suppl 50):S107-9.
8
Systemic Lupus Erythematosus Presenting as Alopecia Areata.表现为斑秃的系统性红斑狼疮
Cureus. 2020 Jun 20;12(6):e8724. doi: 10.7759/cureus.8724.
9
Graves' disease associated with alopecia areata developing after Hashimoto's thyroiditis.格雷夫斯病与桥本甲状腺炎后发生的斑秃相关。
J Nippon Med Sch. 2013;80(6):467-9. doi: 10.1272/jnms.80.467.
10
Screening for an AIRE-1 mutation in patients with Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis as well as in APECED syndrome.对艾迪生病、1型糖尿病、格雷夫斯病和桥本甲状腺炎患者以及自身免疫性多内分泌腺病-念珠菌病-外胚层营养不良综合征患者进行AIRE-1突变筛查。
Clin Endocrinol (Oxf). 2001 Mar;54(3):335-8. doi: 10.1046/j.1365-2265.2001.01230.x.
引用本文的文献
1
Insights into the gut microbiome of vitiligo patients from India.印度白癜风患者的肠道微生物组研究进展。
BMC Microbiol. 2024 Oct 28;24(1):440. doi: 10.1186/s12866-024-03529-5.
2
Acquired Idiopathic Generalized Anhidrosis (AIGA) and Its Complications: Implications for AIGA as an Autoimmune Disease.获得性特发性全身性无汗症（AIGA）及其并发症：将 AIGA 视为自身免疫性疾病的意义。
Int J Mol Sci. 2021 Aug 4;22(16):8389. doi: 10.3390/ijms22168389.
3
The effects of tacrolimus plus phototherapy in the treatment of vitiligo: a meta-analysis.他克莫司联合光疗治疗白癜风的效果：一项荟萃分析。
Arch Dermatol Res. 2021 Aug;313(6):461-471. doi: 10.1007/s00403-020-02121-x. Epub 2020 Aug 12.
4
Serum Zinc Level in Vitiligo: A Case-control Study.白癜风患者血清锌水平：一项病例对照研究。
Indian J Dermatol. 2018 May-Jun;63(3):227-230. doi: 10.4103/ijd.IJD_457_16.
5
Prevalence and Clinical Characteristics of Itch in Vitiligo and Its Clinical Significance.白癜风瘙痒的患病率、临床特征及其临床意义
Biomed Res Int. 2017;2017:5617838. doi: 10.1155/2017/5617838. Epub 2017 Jul 30.
6
Immune and molecular correlates in melanoma treated with immune checkpoint blockade.接受免疫检查点阻断治疗的黑色素瘤中的免疫与分子关联
Cancer. 2017 Jun 1;123(S11):2143-2153. doi: 10.1002/cncr.30444.
7
Evaluation of the serum zinc level in patients with vitiligo.白癜风患者血清锌水平的评估。
Postepy Dermatol Alergol. 2017 Apr;34(2):116-119. doi: 10.5114/ada.2017.67073. Epub 2017 Apr 13.
8
Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity.埃及非节段性白癜风患者循环调节性T细胞减少：与疾病活动度的相关性
Dermatol Res Pract. 2015;2015:145409. doi: 10.1155/2015/145409. Epub 2015 Dec 15.
9
Immunological Parameters Associated With Vitiligo Treatments: A Literature Review Based on Clinical Studies.白癜风治疗相关的免疫学参数：基于临床研究的文献综述
Autoimmune Dis. 2015;2015:196537. doi: 10.1155/2015/196537. Epub 2015 Sep 17.
10
Treatment of vitiligo vulgaris with the combination therapy of topical steroid and vitamin D3 compound.外用糖皮质激素与维生素D3复方联合治疗寻常型白癜风
Dermatol Reports. 2012 Jun 6;4(1):e8. doi: 10.4081/dr.2012.e8. eCollection 2012 Jan 2.
本文引用的文献
1
Th17 cells and activated dendritic cells are increased in vitiligo lesions.白癜风皮损中 Th17 细胞和活化的树突状细胞增加。
PLoS One. 2011 Apr 25;6(4):e18907. doi: 10.1371/journal.pone.0018907.
2
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.乳糜泻和类风湿关节炎全基因组关联研究的荟萃分析确定了 14 个非 HLA 共享位点。
PLoS Genet. 2011 Feb;7(2):e1002004. doi: 10.1371/journal.pgen.1002004. Epub 2011 Feb 24.
3
T cell receptor recognition of self and foreign antigens in the induction of autoimmunity.T 细胞受体识别自身和外来抗原在自身免疫中的诱导作用。
Semin Immunol. 2011 Apr;23(2):84-91. doi: 10.1016/j.smim.2011.01.007.
4
Discovery of a viral NLR homolog that inhibits the inflammasome.发现一种病毒 NLR 同源物，可抑制炎症小体。
Science. 2011 Jan 21;331(6015):330-4. doi: 10.1126/science.1199478.
5
The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease.CIAS1/NALP3/NLRP3 基因中的错义变异 Q705K 和 NLRP1 单倍型与乳糜泻有关。
Am J Gastroenterol. 2011 Mar;106(3):539-44. doi: 10.1038/ajg.2010.474. Epub 2011 Jan 18.
6
Role of interleukin-17 in the pathogenesis of vitiligo.白细胞介素-17 在白癜风发病机制中的作用。
Clin Exp Dermatol. 2011 Apr;36(3):292-7. doi: 10.1111/j.1365-2230.2010.03972.x. Epub 2010 Dec 24.
7
Autoantibodies against tyrosine hydroxylase in patients with non-segmental (generalised) vitiligo.非节段性（泛发性）白癜风患者的酪氨酸羟化酶自身抗体。
Exp Dermatol. 2011 Jan;20(1):35-40. doi: 10.1111/j.1600-0625.2010.01181.x.
8
Mechanisms for T cell receptor triggering.T 细胞受体触发的机制。
Nat Rev Immunol. 2011 Jan;11(1):47-55. doi: 10.1038/nri2887. Epub 2010 Dec 3.
9
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases.人类自身免疫性疾病中 CD4(+)CD25(+)FOXP3(+)调节性 T 细胞功能障碍的调节机制。
Nat Rev Immunol. 2010 Dec;10(12):849-59. doi: 10.1038/nri2889.
10
Vitiligo autoantigen VIT75 is identified as lamin A in vitiligo by serological proteome analysis based on mass spectrometry.基于质谱的血清蛋白质组分析鉴定出白癜风自身抗原 VIT75 为层粘连蛋白 A。
J Invest Dermatol. 2011 Mar;131(3):727-34. doi: 10.1038/jid.2010.341. Epub 2010 Nov 18.
Zotero 插件