Oiso Naoki, Suzuki Tamio, Fukai Kazuyoshi, Katayama Ichiro, Kawada Akira
Department of Dermatology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Dermatol Res Pract. 2011;2011:518090. doi: 10.1155/2011/518090. Epub 2011 Jul 26.
Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo.
非节段性白癜风是一种皮肤色素脱失性疾病，表现为皮肤、黏膜和毛发出现后天性、进行性色素脱失性损害。据信其主要由受累部位黑素细胞的自身免疫性丧失所致。它常与其他自身免疫性疾病相关，尤其是自身免疫性甲状腺疾病，包括桥本甲状腺炎和格雷夫斯病、类风湿关节炎、1型糖尿病、银屑病、恶性贫血、系统性红斑狼疮、艾迪生病和斑秃。这表明不仅对白癫风，而且对其他自身免疫性疾病存在遗传决定的易感性。在此，我们总结了目前对非节段性白癜风自身免疫发病机制的认识。
