辅酶B12的二甲基苯并咪唑配体在生理条件下通过简便的氧化级联反应形成。
Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade.
作者信息
Maggio-Hall Lori A, Dorrestein Pieter C, Escalante-Semerena Jorge C, Begley Tadhg P
机构信息
Department of Bacteriology, University of Wisconsin, 1710 University Avenue, Madison, WI 53726-4087, USA.
出版信息
Org Lett. 2003 Jun 26;5(13):2211-3. doi: 10.1021/ol034530m.
PMID:12816411
Abstract
Dimethylbezimidazole, the axial ligand of vitamin B(12), is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions. [reaction: see text]
摘要
二甲基苯并咪唑是维生素B12的轴向配体，由核黄素通过两步双电子氧化、一步逆羟醛缩合反应以及第二步双电子氧化反应合成。这种氧化级联反应在生理条件下很容易在非酶作用下发生。[反应：见正文]
Zotero 插件