在三氟乙醇中，使用[羟基（对甲苯磺酰氧基）碘]苯通过N-甲氧基-（4-卤代苯基）酰胺的分子内ipso-环化反应合成螺二烯酮。
Synthesis of spirodienones by intramolecular ipso-cyclization of N-methoxy-(4-halogenophenyl)amides using [hydroxy(tosyloxy)iodo]benzene in trifluoroethanol.
作者信息
Miyazawa Etsuko, Sakamoto Takeshi, Kikugawa Yasuo
机构信息
Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
出版信息
J Org Chem. 2003 Jun 27;68(13):5429-32. doi: 10.1021/jo034318w.
PMID:12816516
Abstract
Spirodienones bearing the 1-azaspiro[4.5]decane ring system have been synthesized from N-methoxy-(4-halogenophenyl)amides by the intramolecular ipso attack of a nitrenium ion generated with [hydroxy(tosyloxy)iodo]benzene in trifluoroethanol.
摘要
带有1-氮杂螺[4.5]癸烷环系的螺二烯酮已由N-甲氧基-(4-卤代苯基)酰胺通过在三氟乙醇中用[羟基(甲苯磺酰氧基)碘]苯生成的氮鎓离子进行分子内本位进攻而合成。
Zotero 插件