利用自由基串联反应全合成（±）-百部酰胺和（±）-异百部酰胺。
Total synthesis of (+/-)-stemonamide and (+/-)-isostemonamide using a radical cascade.
作者信息
Taniguchi Tsuyoshi, Tanabe Genzo, Muraoka Osamu, Ishibashi Hiroyuki
机构信息
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
出版信息
Org Lett. 2008 Jan 17;10(2):197-9. doi: 10.1021/ol702563p. Epub 2007 Dec 20.
PMID:18092788
Abstract
Total synthesis of stemonamide and isostemonamide is described. The concise construction of the tricyclic core of these alkaloids was achieved by radical cascade involving 7-endo and 5-endo cyclizations.
摘要
描述了百部酰胺和异百部酰胺的全合成。这些生物碱三环核心的简洁构建是通过涉及7-内型和5-内型环化的自由基串联反应实现的。
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