Sun Tie-ying, Guo Yan-fei, Zhang Hong-sheng
Department of respiratory medicine, Beijing Hospital, Beijing 100730, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2003 Mar;26(3):148-51.
To explore the role of eosinophil cationic protein (ECP) and T lymphocytes in exercise-induced asthma (EIA).
In 32 patients with asthma (13 patients with EIA) and 8 normal subjects, peripheral blood ECP, CD(25)(+)%, and IL-5 mRNA were measured before, 10 min and 60 min after exercise testing.
(1) There was a linear relationship between ECP, CD(25)(+)% and the forced expiratory volume in one second (FEV(1)) before exercise (r = -0.79, -0.61, P < 0.01). (2) In patients with EIA, FEV(1) and PEF decreased remarkably after exercise test, but in patients without EIA, FEV(1) and PEF did not change. The difference between the two groups was significant. (3) There was no significant difference between the two groups in terms of ECP, CD(25)(+)%, and IL-5 mRNA.
T lymphocyte activation and ECP secreted by eosinophils do not seem to play a major role in EIA.
探讨嗜酸性粒细胞阳离子蛋白（ECP）和T淋巴细胞在运动诱发哮喘（EIA）中的作用。
对32例哮喘患者（13例运动诱发哮喘患者）和8名正常受试者，在运动试验前、运动后10分钟和60分钟测量外周血ECP、CD(25)(+)%和IL-5 mRNA。
（1）运动前ECP、CD(25)(+)%与一秒用力呼气容积（FEV(1)）之间存在线性关系（r = -0.79，-0.61，P < 0.01）。（2）运动诱发哮喘患者运动试验后FEV(1)和呼气峰流速（PEF）显著下降，而无运动诱发哮喘患者FEV(1)和PEF无变化。两组间差异有统计学意义。（3）两组在ECP、CD(25)(+)%和IL-5 mRNA方面无显著差异。
T淋巴细胞活化和嗜酸性粒细胞分泌的ECP在运动诱发哮喘中似乎不起主要作用。
