Butolin E G, Danilov G E
Biull Eksp Biol Med. 1992 Jul;114(8):120-2.
The metabolism of connective tissue biopolymers in the blood serum and in the aorta under repeated intraventricular injections of P-substance, L-enkephalin and B-endorphine was studied in chronic experiments on rabbits. The alternations of the central neurochemical processes, caused by prolonged intraventricular injections of neuropeptides were proved to lead to intensification of metabolic processes in the connective tissue characterized by the accumulation of its biopolymers in the aorta wall. The injection of P-substance, in contrast to opioid peptides, is accompanied by more marked alternations.
在对兔子进行的慢性实验中，研究了在反复脑室内注射P物质、L-脑啡肽和β-内啡肽的情况下，血清和主动脉中结缔组织生物聚合物的代谢情况。事实证明，长期脑室内注射神经肽所引起的中枢神经化学过程的改变，会导致结缔组织中代谢过程的强化，其特征是生物聚合物在主动脉壁中积累。与阿片样肽相比，注射P物质时伴随的变化更为明显。
