Brunet F, Mira J P, Belghith M, Lanore J J, Schlumberger S, Toulon P, Dhainaut J F
Medical Intensive Care Unit, Cochin-Port Royal University, Paris, France.
Intensive Care Med. 1992;18(6):364-7. doi: 10.1007/BF01694366.
The effects of aprotinin, a broad-based proteinase inhibitor, in the management of hemorrhagic complications during prolonged venovenous extracorporeal CO2 removal in patients with adult respiratory distress syndrome are not evaluated. In two patients, aprotinin infusion was added to heparin to treat bleeding, occurring after few days of bypass and responsible for respiratory and hemodynamic deterioration. After aprotinin infusion (loading dose of 2 x 10(6) kIU followed by a continuous infusion of 5 x 10(5) kIU/h) combined with heparin, bleeding vanished until the end of bypass.
抑肽酶（一种广谱蛋白酶抑制剂）在成人呼吸窘迫综合征患者长时间静脉-静脉体外二氧化碳清除过程中对出血并发症的管理效果尚未得到评估。在两名患者中，在旁路手术数天后出现出血并导致呼吸和血流动力学恶化，于是在肝素治疗基础上加用抑肽酶输注来治疗出血。在抑肽酶输注（负荷剂量为2×10⁶kIU，随后持续输注5×10⁵kIU/h）联合肝素治疗后，出血在旁路手术结束前消失。
