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蛛网膜下腔小剂量布比卡因与利多卡因用于宫颈环扎术的比较

Subarachnoid small-dose bupivacaine versus lidocaine for cervical cerclage.

作者信息

Beilin Yaakov, Zahn Jeffrey, Abramovitz Sharon, Bernstein Howard H, Hossain Sabera, Bodian Carol

机构信息

Department of Anesthesiology, Mount Sinai School of Medicine, New York University, New York 10029, USA.

出版信息

Anesth Analg. 2003 Jul;97(1):56-61, table of contents. doi: 10.1213/01.ane.0000068940.36040.54.

Abstract

UNLABELLED

Cervical cerclage is often performed as an outpatient procedure under subarachnoid anesthesia. Lidocaine was historically the drug of choice for short procedures but has fallen out of favor because of concerns of transient neurologic symptoms (TNS). We performed this study to determine whether small-dose bupivacaine is an acceptable alternative to lidocaine for cervical cerclage. We randomized 59 women to receive either subarachnoid isobaric lidocaine 30 mg or hyperbaric bupivacaine 5.25 mg. Fentanyl 20 micro g was added to both local anesthetics, and the total volume was diluted to 3 mL with 0.9% saline. Onset and highest dermatomal level of sensory block; quality of anesthesia; hypotension; and times until T12 regression, return of lower extremity motor function, ambulation, and micturition were recorded. Symptoms of TNS were evaluated by telephone interview 24 h after surgery. We did not find any significant difference in onset or recovery times between the groups, with the exception of a longer duration until return of lower extremity motor strength in the lidocaine group. Symptoms consistent with TNS that resolved spontaneously within 48 h were reported by two women in the lidocaine group but by none in the bupivacaine group. We conclude that subarachnoid bupivacaine offers a satisfactory alternative to subarachnoid lidocaine for cervical cerclage.

IMPLICATIONS

We found that small-dose subarachnoid bupivacaine (5.25 mg) with fentanyl 20 micro g provides reliable anesthesia for cervical cerclage and exhibits a pharmacodynamic profile similar to that of small-dose lidocaine.

摘要

未标注

宫颈环扎术通常在蛛网膜下腔麻醉下作为门诊手术进行。利多卡因在历史上是短时间手术的首选药物,但由于对短暂性神经症状(TNS)的担忧,已不再受青睐。我们进行这项研究以确定小剂量布比卡因是否是宫颈环扎术替代利多卡因的可接受选择。我们将59名女性随机分为两组,分别接受30mg蛛网膜下腔等比重利多卡因或5.25mg高比重布比卡因。两种局麻药均加入20μg芬太尼,并用0.9%生理盐水将总体积稀释至3mL。记录感觉阻滞的起效时间和最高皮节水平、麻醉质量、低血压以及直至T12感觉恢复、下肢运动功能恢复、可步行和排尿的时间。术后24小时通过电话访谈评估TNS症状。我们发现两组之间在起效时间或恢复时间上没有显著差异,但利多卡因组下肢运动力量恢复的持续时间更长。利多卡因组有两名女性报告了与TNS一致且在48小时内自发缓解的症状,而布比卡因组则无。我们得出结论,蛛网膜下腔布比卡因是宫颈环扎术替代蛛网膜下腔利多卡因的令人满意的选择。

启示

我们发现,含20μg芬太尼的小剂量蛛网膜下腔布比卡因(5.25mg)可为宫颈环扎术提供可靠的麻醉,并且其药效学特征与小剂量利多卡因相似。

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