人乳头瘤病毒18型E2蛋白中的一个辅助性T细胞表位与一个主要B细胞表位重叠。

A T-helper cell epitope overlaps a major B-cell epitope in human papillomavirus type 18 E2 protein.

作者信息

Lehtinen M, Stellato G, Hyöty H, Nieminen P, Vesterinen E, Paavonen J

机构信息

Institute of Biomedical Sciences, University of Tampere, Finland.

出版信息

APMIS. 1992 Nov;100(11):1022-6. doi: 10.1111/j.1699-0463.1992.tb04035.x.

DOI:10.1111/j.1699-0463.1992.tb04035.x

PMID:1282020

Abstract

Cultivated CD4+ T-helper cells from two patients with cervical adenocarcinoma showed responses to a peptide EKTGILTVTYHSETQRTK derived from an E2 protein of human papillomavirus type 18 (HPV 18), but not to a corresponding HPV 16 peptide (HKSAIVTLTYDSEWQRDQ). Serum antibodies in the HPV 18 peptide were also demonstrated in these patients. The GILT motif resembles a common pattern present in many T-cell epitopes, and is located at the beginning of an 11-amino acid-long A-helix structure close to the carboxyterminal end of HPV 18 E2. We conclude that two epitopes (a T-helper cell epitope and a B-cell epitope) overlap in the HPV 18 E2.

摘要

来自两名宫颈腺癌患者的培养CD4 +辅助性T细胞对源自人乳头瘤病毒18型（HPV 18）E2蛋白的肽EKTGILTVTYHSETQRTK有反应，但对相应的HPV 16肽（HKSAIVTLTYDSEWQRDQ）无反应。这些患者血清中也检测到了针对HPV 18肽的抗体。GILT基序类似于许多T细胞表位中存在的常见模式，位于靠近HPV 18 E2羧基末端的11个氨基酸长的α螺旋结构的起始处。我们得出结论，HPV 18 E2中存在两个重叠表位（一个辅助性T细胞表位和一个B细胞表位）。