风湿性疾病患者的肿瘤型M2丙酮酸激酶血浆水平
Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.
作者信息
Oremek G M, Müller R, Sapoutzis N, Wigand R
机构信息
Central Laboratory, Hospital of the Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.
出版信息
Anticancer Res. 2003 Mar-Apr;23(2A):1131-4.
BACKGROUND
Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases.
MATERIALS AND METHODS
We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rheumatic diseases.
RESULTS
The tumor M2-PK concentration was increased in 52 out of 63 patients (82%) with classical rheumatoid arthritis, in 15 out of 21 patients (71%) with systemic lupus erythematosus, in 14 out of 17 patients (82%) with seronegative spondylarthritis and in 13 out of 28 patients with miscellaneous rheumatic diseases (46%). Malignant neoplasm was not detected in any of the patients with rheumatic diseases.
CONCLUSION
These results demonstrated that the EDTA-plasma concentrations of Tumor M2-PK were increased in patients with rheumatic diseases.
背景
由于肿瘤标志物在许多良性疾病过程中可能会升高，本研究的目的是验证在风湿性疾病过程中是否也会出现这种情况。
材料与方法
我们调查了137例风湿性疾病患者乙二胺四乙酸（EDTA）血浆中肿瘤M2-PK的发生率和特征。
结果
63例经典类风湿关节炎患者中有52例（82%）肿瘤M2-PK浓度升高，21例系统性红斑狼疮患者中有15例（71%）升高，17例血清阴性脊柱关节炎患者中有14例（82%）升高，28例其他风湿性疾病患者中有13例（46%）升高。在任何风湿性疾病患者中均未检测到恶性肿瘤。
结论
这些结果表明，风湿性疾病患者的EDTA血浆中肿瘤M2-PK浓度升高。
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