Gunawan Bastian, Baumhoer Daniel, Schulten Hans-Jürgen, Emons Günter, Füzesi László
Institute of Pathology, Georg August University Hospital, Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.
Anticancer Res. 2003 Mar-Apr;23(2B):1379-83.
Unique genetical gain of 8q and/or polysomy 8 identified after short-term culture are presented in three cases of malignant mixed Müllerian tumors (MMMT) of the uterus. All tumors revealed abnormal karyotypes and modal chromosome numbers in the hyperdiploid range. Two out of three cases exclusively demonstrated numerical aberrations, most prominently polysomy 8. One tumor revealed tetrasomy 8 as the sole aberration. The third tumor showed a more complex karyotype, including two unbalanced translocations, leading to partial gain of 8q. These cytogenetic findings, together with 14 previously reported cases of MMMT and 5 cell lines, suggest a distinct subgroup of endometrial MMMT characterized by gain of chromosome 8 or 8q.
在三例子宫恶性混合性苗勒管肿瘤（MMMT）中，呈现出短期培养后鉴定出的8号染色体长臂独特遗传增益和/或8号染色体多倍体。所有肿瘤均显示异常核型，且众数染色体数处于超二倍体范围内。三例中有两例仅表现出数量畸变，最显著的是8号染色体多倍体。一例肿瘤显示8号染色体四体性为唯一畸变。第三例肿瘤显示出更复杂的核型，包括两个不平衡易位，导致8号染色体长臂部分增益。这些细胞遗传学发现，连同之前报道的14例MMMT病例和5个细胞系，提示存在一个以8号染色体或8号染色体长臂增益为特征的子宫内膜MMMT独特亚组。
