Khalyavkin A V, Yashin A I
Institute of Biochemical Physics of RAS, Moscow 119991, Russia.
Adv Gerontol. 2003;11:34-42.
The results of recent molecular biological studies of aging and longevity confirmed substantial genetic contribution to the life span. The analysis of these findings showed substantial role of specific mutations in genes involved in regulatory processes on both the extra- and intracellular levels. We suggest that difference in responses of intact and mutant animals to the same set of environmental signals may be useful to clarify contribution of organism-environment interactions into the rate of aging, mortality and longevity of respective organisms. In our opinion such clarification is important for better understanding the origin of natural senescence and its dependence on external conditions.
近期关于衰老和长寿的分子生物学研究结果证实，基因对寿命有重大影响。对这些研究结果的分析表明，特定突变在细胞外和细胞内水平参与调节过程的基因中发挥着重要作用。我们认为，完整动物和突变动物对同一组环境信号的反应差异，可能有助于阐明生物体与环境相互作用对各生物体衰老速度、死亡率和寿命的影响。我们认为，这种阐明对于更好地理解自然衰老的起源及其对外部条件的依赖性很重要。
