Bossaller C, Auch-Schwelk W, Graf K, Gräfe M, Catadelgirmen G, Ennker J, Fleck E
German Heart Institute Berlin, Department of Internal Medicine and Cardiology.
J Cardiovasc Pharmacol. 1992;20 Suppl 3:S13-6. doi: 10.1097/00005344-199206203-00004.
Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 >> nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >> nicorandil in human arteria mammaria. These data demonstrate that K(+)-channel openers are effective vasorelaxant agents in human coronary artery and human arteria mammaria. Bimakalim and EMD 56431 were more potent than nicorandil, a drug that also activates guanylate cyclase.
对三种具有钾通道开放活性的药物——尼可地尔、比马卡林（EMD 52692）和EMD 56431——进行了人体冠状动脉和乳腺动脉血管舒张能力测试。在人体冠状动脉中，舒张效力顺序为比马卡林 = EMD 56431 >> 尼可地尔；在人体乳腺动脉中，舒张效力顺序为比马卡林 = EMD 56431 >> 尼可地尔。这些数据表明，钾通道开放剂在人体冠状动脉和乳腺动脉中是有效的血管舒张剂。比马卡林和EMD 56431比尼可地尔更有效，尼可地尔是一种也能激活鸟苷酸环化酶的药物。
