雌激素对雌性大鼠骨关节炎影响的实验研究
[An experimental study on effect of estrogen on osteoarthritis in female rats].
作者信息
Ren Yong-xin, Deng You-zhang
机构信息
Department of Orthopedics, Affiliated Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu Sichuan, P.R. China 610072.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2003 May;17(3):212-4.
OBJECTIVE
To investigate the effect of estrogen on osteoarthritis in female rats.
METHODS
Forty female rats were divided into four groups. In group I, the rats were not given any treatment as a control. In groups II, III and IV, the rats received fixing left knee joint on extension position. Meanwhile, the rats received ovariectomy in group III; ovariectomy and diethylstilbestrol treatment in group IV, respectively. After 4 weeks, histological observation and serum BGP examination were done.
RESULTS
In groups II, III and IV, the levels of serum BGP were 3.50 +/- 0.39, 5.72 +/- 0.64 and 3.95 +/- 0.44, respectively. The pathologic grades of cartilage and synovium were 10.83 +/- 4.35 and 4.21 +/- 2.03; 15.32 +/- 3.42 and 7.62 +/- 3.42; and 12.65 +/- 2.73 and 5.46 +/- 1.23, respectively.
CONCLUSION
Estrogen may play an important role in delaying the development of osteoarthritis.
目的
探讨雌激素对雌性大鼠骨关节炎的影响。
方法
将40只雌性大鼠分为四组。第一组大鼠不做任何处理作为对照。第二、三、四组大鼠将左膝关节固定于伸展位。同时，第三组大鼠进行卵巢切除术；第四组大鼠分别进行卵巢切除术及己烯雌酚治疗。4周后，进行组织学观察及血清骨钙素（BGP）检测。
结果
第二、三、四组大鼠血清BGP水平分别为3.50±0.39、5.72±0.64和3.95±0.44。软骨和滑膜的病理分级分别为10.83±4.35和4.21±2.03；15.32±3.42和7.62±3.42；以及12.65±2.73和5.46±1.23。
结论
雌激素可能在延缓骨关节炎发展中起重要作用。
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