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[图兹拉州新生儿甲状腺肿的发生率、尿碘排泄及促甲状腺激素水平]

[Occurrence of goiter, urinary iodine excretion and TSH in neonates in the Tuzla Canton].

作者信息

Toromanović Alma, Tahirović Husref, Kusić Zvonko

机构信息

Klinika za djecije bolesti, Univerzitetski klinicki centar Tuzla.

出版信息

Med Arh. 2003;57(2):75-80.

PMID:12822378
Abstract

Goiter frequency and urinary iodine excretion levels were assessed in schoolchildren, aged 7-15 years, living in Tuzla Canton. Goiter frequency was evaluated by clinical examination and ultrasound of the thyroid gland. Goiter by inspection and palpation was found in 19.1% of all subjects, in 19.8% of girls and 18.4% of boys. With regard to updated reference values for thyroid volume reported by WHO and ICCIDD, goiter by ultrasonography was found in 12.9% (n = 62) of all subjects (n = 480). Median urinary iodine was 71.0 micrograms/L. Mild iodine deficiency is observed in Tuzla Canton, based on goiter frequency and urinary iodine excretion. Neonatal TSH results, obtained in the programme of the neonatal thyroid screening, were also analyzed. The frequency of neonatal TSH above 5 mU/L was 12.0% indicating, as two other indicators, mild degree of iodine deficiency in this region. The results underline the inefficacy of iodine prophylaxis with 10 mg K1 per kg of salt in correcting iodine deficiency. On the basis of the study, carried out in the rest of the Federation of Bosnia and Herzegovina, the new regulation was proclaimed in 2001 requiring 20-30 mg of iodine per kg of salt.

摘要

对居住在图兹拉州的7至15岁学童的甲状腺肿发病率和尿碘排泄水平进行了评估。通过临床检查和甲状腺超声评估甲状腺肿发病率。通过视诊和触诊发现,所有受试者中甲状腺肿的发生率为19.1%,女孩为19.8%,男孩为18.4%。根据世界卫生组织(WHO)和国际控制碘缺乏病理事会(ICCIDD)报告的甲状腺体积最新参考值,所有受试者(n = 480)中通过超声检查发现甲状腺肿的比例为12.9%(n = 62)。尿碘中位数为71.0微克/升。根据甲状腺肿发病率和尿碘排泄情况,图兹拉州存在轻度碘缺乏。还对新生儿甲状腺筛查项目中获得的新生儿促甲状腺激素(TSH)结果进行了分析。新生儿TSH高于5 mU/L的频率为12.0%,这与其他两项指标一样,表明该地区存在轻度碘缺乏。结果强调了每公斤盐中添加10毫克碘化钾(K1)的碘预防措施在纠正碘缺乏方面的无效性。根据在波斯尼亚和黑塞哥维那联邦其他地区进行的研究,2001年宣布了新规定,要求每公斤盐含碘20 - 30毫克。

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