Zhao Jing, Wilkins Richard M
Department of Agricultural and Environmental Science, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom.
J Agric Food Chem. 2003 Jul 2;51(14):4023-8. doi: 10.1021/jf026092o.
An organosolv lignin and several of its fractions were used to prepare controlled release matrix granules with fluometuron using a melt process. Release profiles of fluometuron from these granules and a commercial granular formulation were studied in vitro. The release rates of fluometuron were considerably reduced from all lignin-based granules as compared to the commercial formulation. The release rates markedly varied with the lignin fraction used in the fluometuron-lignin matrix systems with the corresponding times for 50% release (T(50)) values ranging from 2.37 to 11.2 days. The variation in release rate of fluometuron was related to the high proportion of low molecular weight lignin and its associated water soluble lignin in the lignin-based granules, in terms of the hydrophobicity of matrix, the content, and release rate of soluble lignin. The release kinetics were fitted to the generalized model for up to 60% release of fluometuron; the kinetics of fluometuron were of the anomalous type for all matrixes in which release rates increased following a delay.
采用熔融法，用有机溶剂木质素及其几个级分与伏草隆制备控释基质颗粒。对这些颗粒和一种市售颗粒制剂中伏草隆的体外释放曲线进行了研究。与市售制剂相比，所有木质素基颗粒中伏草隆的释放速率均显著降低。在伏草隆 - 木质素基质体系中，伏草隆的释放速率随所用木质素级分的不同而有显著差异，相应的50%释放时间（T(50)）值在2.37至11.2天之间。就基质的疏水性、可溶性木质素的含量和释放速率而言，伏草隆释放速率的变化与木质素基颗粒中低分子量木质素及其相关水溶性木质素的高比例有关。将释放动力学拟合到伏草隆释放高达60%的通用模型；在所有基质中，伏草隆的动力学均为异常类型，其中释放速率在延迟后增加。
