Ye Yunpeng, Li Wen Ping, Anderson Carolyn J, Kao Jeffery, Nikiforovich Gregory V, Achilefu Samuel
Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
J Am Chem Soc. 2003 Jul 2;125(26):7766-7. doi: 10.1021/ja034186o.
Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.
将一种生物活性肽与一种双功能近红外荧光光学探针进行大环化反应，得到一种化合物，该化合物保留了肽的受体结合亲和力以及光学探针的光物理性质。这种新化合物的稳健特性为优化生物活性分子的活性以及通过近红外光学方法在体内和体外监测化学或生物过程提供了一个结构框架。
