• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.

作者信息

Cohen P L, Eisenberg R A

机构信息

Dept of Medicine, University of North Carolina School of Medicine, Chapel Hill 27599-7280.

出版信息

Immunol Today. 1992 Nov;13(11):427-8. doi: 10.1016/0167-5699(92)90066-G.

DOI:10.1016/0167-5699(92)90066-G
PMID:1282318
Abstract

The single gene lpr and gld models of spontaneous systemic autoimmunity have attracted much attention in recent years. Here, Philip Cohen and Robert Eisenberg describe the fascinating recent findings that the lpr and gld [corrected] phenotypes result from defects in the Fas gene and, perhaps, in the ligand for fas, respectively.

摘要

相似文献

1
The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.
Immunol Today. 1992 Nov;13(11):427-8. doi: 10.1016/0167-5699(92)90066-G.
2
Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice.自身免疫性lpr和gld小鼠脾脏淋巴细胞的凋亡异常
J Immunol. 1995 Jan 15;154(2):936-43.
3
gld/gld mice are unable to express a functional ligand for Fas.gld/gld小鼠无法表达功能性Fas配体。
Eur J Immunol. 1994 Apr;24(4):928-33. doi: 10.1002/eji.1830240422.
4
Cellular interactions in the lpr and gld models of systemic autoimmunity.系统性自身免疫的lpr和gld模型中的细胞相互作用。
Adv Dent Res. 1996 Apr;10(1):76-80. doi: 10.1177/08959374960100011601.
5
Murine models of autoimmunity: T-cell and B-cell defects.自身免疫的小鼠模型：T 细胞和 B 细胞缺陷
Curr Opin Rheumatol. 1992 Oct;4(5):612-20.
6
Oncogene expression in autoimmune mice.自身免疫小鼠中的癌基因表达。
J Mol Cell Immunol. 1985;2(3):121-31.
7
Autoimmunity in mice bearing lprcg: a novel mutant gene.携带lprcg的小鼠中的自身免疫：一个新的突变基因。
Int Rev Immunol. 1994;11(3):193-210. doi: 10.3109/08830189409061727.
8
In vivo depletion of Thy-1-positive cells originating from normal bone marrow abrogates the suppression of gld disease in normal-gld mixed bone marrow chimeras.体内去除源自正常骨髓的Thy-1阳性细胞可消除正常-gld混合骨髓嵌合体中gld疾病的抑制作用。
J Immunol. 1995 Jan 1;154(1):444-9.
9
Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model.人类自身免疫性淋巴细胞增生综合征，一种凋亡诱导性Fas受体缺陷：来自小鼠模型的教训。
J Hum Genet. 1998;43(1):2-8. doi: 10.1007/s100380050029.
10
Co-infusion of normal bone marrow partially corrects the gld T-cell defect. Evidence for an intrinsic and extrinsic role for Fas ligand.正常骨髓的共同输注可部分纠正gld T细胞缺陷。Fas配体的内在和外在作用的证据。
J Immunol. 1995 Jan 1;154(1):459-64.

引用本文的文献

1
Apoptosis: A Key Process That Modulates as a Strategy to Perpetuate Infection.细胞凋亡：作为使感染持续存在的一种策略进行调节的关键过程。
J Parasitol Res. 2025 Jul 7;2025:2093615. doi: 10.1155/japr/2093615. eCollection 2025.
2
Immunopathogenesis in infection: a role for suppressed macrophages and apoptotic cells.感染的免疫发病机制：受抑制的巨噬细胞和凋亡细胞的作用。
Front Immunol. 2023 Aug 17;14:1244071. doi: 10.3389/fimmu.2023.1244071. eCollection 2023.
3
Gut microbiota in SLE: from animal models to clinical evidence and pharmacological perspectives.
系统性红斑狼疮中的肠道微生物群：从动物模型到临床证据和药理学视角。
Lupus Sci Med. 2023 Feb;10(1). doi: 10.1136/lupus-2022-000776.
4
Analysis of Pharmacological Activities and Mechanisms of Essential Oil in Leaves of 'Tomentosa' by GC-MS/MS and Network Pharmacology.GC-MS/MS 和网络药理学分析香叶精油的药理活性和作用机制。
Comb Chem High Throughput Screen. 2023;26(9):1689-1700. doi: 10.2174/1386207325666220610182644.
5
Emerging Issues Questioning the Current Treatment Strategies for Lumbar Disc Herniation.质疑腰椎间盘突出症当前治疗策略的新问题
Front Surg. 2022 Mar 28;9:814531. doi: 10.3389/fsurg.2022.814531. eCollection 2022.
6
Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases.针对癌症和自身免疫性疾病中 CD95L/CD95 信号的治疗方法。
Cell Death Dis. 2022 Mar 17;13(3):248. doi: 10.1038/s41419-022-04688-x.
7
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis.人脐带间充质干细胞治疗通过 miR-199a-5p/Sirt1/p53 轴增加 CD4+T 细胞衰老改善狼疮。
Theranostics. 2021 Jan 1;11(2):893-905. doi: 10.7150/thno.48080. eCollection 2021.
8
Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus.靶向免疫复合物结合的补体 C3d 配体作为治疗狼疮的新疗法。
J Immunol. 2019 Dec 15;203(12):3136-3147. doi: 10.4049/jimmunol.1900620. Epub 2019 Nov 15.
9
Mouse models of lupus: what they tell us and what they don't.狼疮的小鼠模型：它们告诉了我们什么以及未告诉我们什么。
Lupus Sci Med. 2018 Jan 21;5(1):e000199. doi: 10.1136/lupus-2016-000199. eCollection 2018.
10
A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis.RIP1 在出生后发育和免疫稳态中的新功能是通过防止 RIP3 依赖性坏死和 FADD 介导的细胞凋亡来实现的。
Front Cell Dev Biol. 2015 Feb 25;3:12. doi: 10.3389/fcell.2015.00012. eCollection 2015.