de Carolis Piero, Magnifico Fabiola, Pierangeli Giulia, Rinaldi Rita, Galeotti Massimo, Cevoli Sabina, Cortelli Pietro
Department of Neurological Sciences, University of Bologna, Bologna, Italy.
Epilepsia. 2003 Jul;44(7):974-6. doi: 10.1046/j.1528-1157.2003.40702.x.
Hypohidrosis during topiramate (TPM) treatment was recently reported in children. We describe an adult epilepsy patient who developed inability to sweat as well as heat intolerance while undergoing treatment with TPM.
To detect the site of the sweat block, patient underwent examination of sweat gland function, cardiovascular autonomic test, and body temperature rhythm determination.
During TPM treatment, cardiovascular autonomic function and circadian rhythm of body core temperature were normal, whereas thermoregulatory sweat test (TST) showed anhydrosis. This adverse drug effect was quickly resolved after drug discontinuation.
Because of normal cardiovascular autonomic function and central and peripheral thermoregulatory mechanisms, we hypothesize that hypohidrosis during TPM treatment could be due to a carbonic anhydrases (CA) block at the level of sweat gland.
近期有报道称托吡酯（TPM）治疗期间儿童会出现少汗症。我们描述了一名成年癫痫患者，其在接受TPM治疗时出现了无汗以及不耐热的情况。
为检测汗腺阻滞部位，患者接受了汗腺功能检查、心血管自主神经测试以及体温节律测定。
在TPM治疗期间，心血管自主神经功能以及体核温度的昼夜节律均正常，而体温调节汗液试验（TST）显示无汗。停药后这种药物不良反应迅速得到缓解。
由于心血管自主神经功能以及中枢和外周体温调节机制正常，我们推测TPM治疗期间的少汗症可能是由于汗腺水平的碳酸酐酶（CA）阻滞所致。
