Iznak A F, Chaianov N V, Gavrilova S I, Mikhaĭlova N M, Selezneva N D, Kalyn Ia B, Kolykhalov I V
Vestn Ross Akad Med Nauk. 1992(8):39-41.
EEG topographic correlates of the severity and type of Alzheimer-type dementias have been studied in 21 patients with senile dementia (SD) and 18 with Alzheimer's disease (AD) who were subdivided into smaller groups by MMSE grades for the severity of dementia, as well as in 15 mentally normal elderly persons. EEC maps in SD and AD patients differed from those in normal subjects in increased theta-delta EEG spectral power and suppressed alpha-band power that was more pronounced in the left hemisphere in AD than in SD patients. AD and SD patients had also different EEG topographical changes with intensified cognitive dysfunctions. The results suggest that there is a great cholinergic deficiency and cortical rather than subcortical impairments in patients with AD than in those with SD.
对21例老年痴呆症（SD）患者和18例阿尔茨海默病（AD）患者的脑电图地形图与阿尔茨海默型痴呆症的严重程度和类型之间的相关性进行了研究。这些患者根据简易精神状态检查表（MMSE）的痴呆严重程度等级被细分为更小的组，同时还研究了15名精神正常的老年人。SD和AD患者的脑电图图谱与正常受试者的不同，表现为θ-δ脑电图频谱功率增加，α波段功率受到抑制，这在AD患者的左半球比在SD患者中更为明显。AD和SD患者在认知功能障碍加剧时也有不同的脑电图地形学变化。结果表明，与SD患者相比，AD患者存在严重的胆碱能缺乏和皮质而非皮质下损伤。
