Saligaut C, Garnier D H, Bennani S, Salbert G, Bailhache T, Jego P
Laboratoire de Physiologie des Régulations, U.R.A. CNRS 256, Université de Rennes I, France.
Gen Comp Endocrinol. 1992 Nov;88(2):209-16. doi: 10.1016/0016-6480(92)90252-f.
Brain serotonin and dopamine (DA) turnovers in the female rainbow trout were studied at the beginning of the vitellogenesis and related to blood estradiol (E2) levels; pituitary and plasma gonadotropin (GtH) were also assayed. Ovariectomy did not modify brain aminergic turnover. E2 replacement on ovariectomized fish increased hypothalamic DA turnover (increased DA and increased DA metabolites). E2 stimulated GtH synthesis (positive feedback) but did not enhance GtH release; hypothalamic E2-mediated aminergic inhibition upon release was suspected. Individual relations between blood E2 levels and catecholaminergic neurotransmitters were determined. A linear positive correlation (r = 0.82) was found for the hypothalamus, but not for the pituitary, the preoptic area, or the telencephalon. These data suggest that an activation of hypothalamic tyrosine hydroxylase (the limiting step of catecholamines synthesis) by E2 could develop as vitellogenesis proceeds.
在卵黄生成开始时，研究了雌性虹鳟鱼脑内5-羟色胺和多巴胺（DA）的周转率，并将其与血液雌二醇（E2）水平相关联；同时还检测了垂体和血浆促性腺激素（GtH）。卵巢切除并未改变脑内胺能周转率。对卵巢切除的鱼进行E2替代，可增加下丘脑DA周转率（DA增加且DA代谢产物增加）。E2刺激GtH合成（正反馈），但不增强GtH释放；怀疑下丘脑存在E2介导的胺能对释放的抑制作用。确定了血液E2水平与儿茶酚胺能神经递质之间的个体关系。在下丘脑中发现了线性正相关（r = 0.82），但在垂体、视前区或端脑中未发现。这些数据表明，随着卵黄生成的进行，E2可能会激活下丘脑酪氨酸羟化酶（儿茶酚胺合成的限速步骤）。
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