Montorsi F
Department of Urology, Universita' Vita e Salute San Raffaele, Milan, Italy.
Int J Impot Res. 2003 Apr;15 Suppl 2:S7-9. doi: 10.1038/sj.ijir.3900991.
Apomorphine SL (Ixense (TM) ) (apo SL) is a dopamine receptor agonist that can enhance sexual function in patients with erectile dysfunction (ED). For a patient, the ability to achieve a physiological erection, tolerability, efficacy and the speed of onset of the therapy are of considerable importance when considering ED treatment. Recent studies have focused on determining the patient's tolerability to apo SL as a therapy for ED. In addition, the cardiovascular profile of those patients that would be likely to receive apo SL in the clinic has been assessed. These studies have shown that apo SL is safe and effective in the treatment of ED and offers a new therapeutic option for the first-line treatment of patients with different concomitant diseases including cardiovascular disease and diabetes. The most frequently reported adverse events were nausea and dizziness, but no major adverse events have been noted in any of the clinical trials.
阿扑吗啡口腔崩解片（Ixense™）（阿扑吗啡口腔崩解片）是一种多巴胺受体激动剂，可增强勃起功能障碍（ED）患者的性功能。对于患者而言，在考虑ED治疗时，实现生理性勃起的能力、耐受性、疗效以及治疗起效速度至关重要。最近的研究集中于确定患者对阿扑吗啡口腔崩解片作为ED治疗方法的耐受性。此外，还评估了临床上可能接受阿扑吗啡口腔崩解片治疗的患者的心血管状况。这些研究表明，阿扑吗啡口腔崩解片治疗ED安全有效，为包括心血管疾病和糖尿病在内的患有不同伴发疾病的患者一线治疗提供了新的治疗选择。最常报告的不良事件是恶心和头晕，但在任何临床试验中均未发现重大不良事件。
