Arlettaz Romaine, Paraskevopoulos Elena, Bucher Hans-Ulrich
Neonatal Unit, University Hospital, Zurich, Switzerland.
J Perinat Med. 2003;31(3):242-50. doi: 10.1515/JPM.2003.033.
Main objectives were 1) to determine the incidence of higher multiple births from 1995 to 1998 in Switzerland, and 2) to evaluate neonatal mortality and morbidity. Secondary objectives were 3) to compare the results with those of matched singletons, and 4) to compare the present data to the first Swiss study (1985-1988).
Retrospective analysis of maternal and neonatal data obtained from all Swiss hospitals.
The incidence of triplet births was 1/3247 and that of quadruplet births 1/81,186. The median gestational age was 32 5/7 weeks for triplets, and 28 6/7 weeks for quadruplets. The median birth weight was 1665 g for triplets and 1076 g for quadruplets. Perinatal mortality was 6% for triplets and 19% for quadruplets. Respiratory distress syndrome was the major morbidity as diagnosed in 52% of triplets and 81% of quadruplets. A comparison of triplets with matched singletons showed no significant differences in morbidity and mortality. Compared with the first Swiss study, the mortality rate decreased, while the incidence of triplets increased but decreased for quadruplets.
The incidence of higher-order multiple births in Switzerland dropped for quadruplets in the last decade but has increased for triplets. The mortality and morbidity of triplets is comparable to that of singletons with a similar gestational age.
主要目标为：1）确定1995年至1998年瑞士高阶多胞胎的发生率；2）评估新生儿死亡率和发病率。次要目标为：3）将结果与匹配的单胎进行比较；4）将当前数据与瑞士第一项研究（1985 - 1988年）的数据进行比较。
对从瑞士所有医院获取的孕产妇和新生儿数据进行回顾性分析。
三胞胎的发生率为1/3247，四胞胎的发生率为1/81,186。三胞胎的中位孕周为32又5/7周，四胞胎为28又6/7周。三胞胎的中位出生体重为1665克，四胞胎为1076克。三胞胎的围产期死亡率为6%，四胞胎为19%。呼吸窘迫综合征是主要的发病情况，在52%的三胞胎和81%的四胞胎中被诊断出。三胞胎与匹配的单胎比较显示，发病率和死亡率无显著差异。与瑞士第一项研究相比，死亡率下降，三胞胎的发生率上升，而四胞胎的发生率下降。
在过去十年中，瑞士四胞胎的高阶多胞胎发生率下降，但三胞胎的发生率上升。三胞胎的死亡率和发病率与孕周相似的单胎相当。
