埃皮巴蒂啶：对烟碱受体研究的影响。
Epibatidine: impact on nicotinic receptor research.
作者信息
Dukat Małgorzata, Glennon Richard A
机构信息
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
出版信息
Cell Mol Neurobiol. 2003 Jun;23(3):365-78. doi: 10.1023/a:1023692705700.
Abstract
Epibatidine is a natural product that was isolated and identified by Daly and coworkers in 1992. Since that time, it has had a profound influence on the investigation of alpha4beta2 nicotinic cholinergic (nACh) receptor pharmacophore models, and has inspired the development of novel agents with therapeutic potential in CNS disorders. Apart from acetylcholine and nicotine, probably no other agent has had as much recent impact on nACh research as has epibatidine.
摘要
埃皮巴蒂啶是一种天然产物，1992年由戴利及其同事分离并鉴定出来。从那时起，它对α4β2烟碱型胆碱能（nACh）受体药效团模型的研究产生了深远影响，并激发了在中枢神经系统疾病中具有治疗潜力的新型药物的开发。除了乙酰胆碱和尼古丁外，可能没有其他药物在近期对nACh研究产生过像埃皮巴蒂啶这样大的影响。
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