Chantriolides A和B，两种从箭根薯根茎中分离得到的新的含茄烷类内酯葡萄糖苷。

Chantriolides A and B, two new withanolide glucosides from the rhizomes of Tacca chantrieri.

作者信息

Yokosuka Akihito, Mimaki Yoshihiro, Sashida Yutaka

机构信息

Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

出版信息

J Nat Prod. 2003 Jun;66(6):876-8. doi: 10.1021/np0206099.

DOI:10.1021/np0206099

PMID:12828482

Abstract

Two new withanolide glucosides, chantriolides A (1) and B (2), were isolated from the rhizomes of Tacca chantrieri. Their structures were determined on the basis of extensive spectroscopic studies and by acid hydrolysis as (22R)-1alpha,12alpha-diacetoxy-2alpha,3alpha;6alpha,7alpha-diepoxy-27-[(beta-d-glucopyranosyl)oxy]-5alpha-hydroxy-16-oxowith-24-enolide (1) and (22R)-1alpha,12alpha-diacetoxy-2alpha,3alpha;6alpha,7alpha-diepoxy-27-[(beta-d-glucopyranosyl)oxy]-5alpha,16beta-dihydroxywith-24-enolide (2), respectively. It is notable that withanolides, which have been almost exclusively isolated from plants of the family Solanaceae to date, have been found in a species in the family Taccaceae in the present study.

摘要

从箭根薯的根茎中分离出了两种新的睡茄内酯苷，即箭根薯内酯A（1）和箭根薯内酯B（2）。通过广泛的光谱研究和酸水解确定了它们的结构，分别为(22R)-1α,12α-二乙酰氧基-2α,3α;6α,7α-二环氧-27-[(β-D-吡喃葡萄糖基)氧基]-5α-羟基-16-氧代-24-烯醇内酯（1）和(22R)-1α,12α-二乙酰氧基-2α,3α;6α,7α-二环氧-27-[(β-D-吡喃葡萄糖基)氧基]-5α,16β-二羟基-24-烯醇内酯（2）。值得注意的是，迄今为止几乎仅从茄科植物中分离得到的睡茄内酯，在本研究中却在蒟蒻薯科的一个物种中被发现。