马蹄香中的细胞毒醌型二氢查尔酮化合物——马蹄铃醇
Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.
机构信息
Department of Pharmacology and Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
出版信息
J Nat Prod. 2010 Sep 24;73(9):1590-2. doi: 10.1021/np100350s.
Abstract
A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri. The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC(50) values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.
摘要
一种新型苯醌型反式二氢查耳酮，命名为埃夫林宁，从紫箕的根和根茎中分离得到。该结构是基于光谱数据分析确定的，并通过简单的一步全合成得到证实。埃夫林宁对四种人癌细胞系 MDA-MB-435 黑色素瘤、MDA-MB-231 乳腺癌、PC-3 前列腺癌和 HeLa 宫颈癌具有细胞毒性，IC50 值分别为 4.1、3.9、4.7 和 6.3 μM。
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