Spolidorio L C, Spolidorio D M, Benatti C, Sampaio J E, Almeida O P
Department of Oral Pathology and Periodontology, Dental School, Araraquara, University of State of São Paulo, São Paulo, Brazil.
J Periodontal Res. 2003 Aug;38(4):375-9. doi: 10.1034/j.1600-0765.2003.00014.x.
Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity.
The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently.
Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow.
Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine.
These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.
环孢素A和硝苯地平可导致大鼠牙龈增生，联合使用这些药物会增加增生的严重程度。
本研究旨在比较单独使用或同时给予环孢素A和硝苯地平治疗的不同年龄大鼠的牙龈增生情况。
对15日龄、30日龄、60日龄和90日龄的大鼠，在饲料中给予10mg/kg体重的环孢素A和/或50mg/kg体重的硝苯地平。
幼龄大鼠在给予硝苯地平、环孢素A以及同时给予环孢素A和硝苯地平时均出现明显的牙龈增生。成年大鼠单独使用环孢素A和硝苯地平治疗时未出现明显的牙龈改变。然而，当同时给予环孢素A和硝苯地平时，观察到明显的牙龈增生以及上皮和结缔组织的改变。
这些结果表明，环孢素A和硝苯地平联合对大鼠牙龈增生的影响与年龄无关。
